Zhengbo Zhu, H. Chandak, D. Seidel
Jun 25, 2018
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0
Influential Citations
12
Citations
Journal
Organic letters
Abstract
Amines such as 1,2,3,4-tetrahydroisoquinoline undergo redox-neutral annulations with 2-(2-oxoethyl)malonates in the presence of catalytic amounts of benzoic acid. These reactions install a fully saturated five-membered ring and provide access to structures closely related to the natural products crispine A and harmicine.