Anirudra Paul, H. Chandak, Longle Ma
Jan 27, 2020
Citations
0
Influential Citations
10
Citations
Journal
Organic letters
Abstract
Amines such as 1,2,3,4-tetrahydroisoquinoline undergo redox-neutral annulations with ortho-cyanomethylbenzaldehydes. These amine α-C-H bond functionalization reactions are promoted by acetic acid. The resulting β-aminonitriles can be converted to the corresponding β-aminoalcohols in diastereoselective fashion.