A. H. Essa, R. I. Lerrick, F. Tuna
Mar 7, 2013
Citations
1
Influential Citations
16
Citations
Journal
Chemical communications
Abstract
2,2,2-Trichloro-1-arylethanones undergo high yielding reductions to the corresponding 2,2-dichloro-1-arylethanones in the presence of RMgX. A single electron transfer mechanism for the reaction is proposed based on trapping experiments. Reaction of the intermediate enolates with a range of electrophiles is described, providing a convenient route to substituted α,α-dichloro-β-hydroxyketones and related molecules.