K. Ishihara, N. Nakajima, H. Yamaguchi
Sep 28, 2001
Citations
0
Influential Citations
12
Citations
Journal
Journal of Molecular Catalysis B-enzymatic
Abstract
Abstract It was found that α- and β-keto esters were converted to the corresponding hydroxy esters by marine micro algae. Ethyl 2-methyl-3-oxobutanoate was reduced by Nannochloropsis sp. to the anti-hydroxy ester with excellent diastereo- (syn/anti=1:99) and high enantioselectivity (anti >99%, syn 98%). The stereocontrolled reduction of ethyl 3-methyl-2-oxobutanoate was accomplished by Nannochloropsis sp. or Chaetoceros gracilis in the presence of l -lactic acid as an additive.