M. Fyfe, C. Rasamison
Apr 1, 2005
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Influential Citations
3
Citations
Journal
Organic Preparations and Procedures International
Abstract
Cyclobutyl phenyl sulfide (1) is a precursor of cyclobutyl phenyl sulfoxide, a reagent extremely useful for the synthesis of spirocyclic cyc1opentanones.l” In our laboratories, we required a method for the large scale production of 1, a compound necessary for the construction of a range of potent glucokinase activators (GKAs)~ that could form the basis of a treatment for type 2 diabetes. Here, we discuss how the difficulties associated with previous syntheses’ of 1 were overcome by the development of a novel synthetic route that relies upon a modified reductive thiolation’ protocol.