Saki Ichikawa, Xi-Jie Dai, S. Buchwald
May 17, 2019
Citations
0
Influential Citations
27
Citations
Journal
Organic letters
Abstract
A highly regio- and enantioselective synthesis of 1,2-diamine derivatives from γ-substituted allylic pivalamides using copper-catalyzed hydroamination is reported. The N-pivaloyl group is essential, in both facilitating the hydrocupration step and suppressing an unproductive β-elimination from the alkylcopper intermediate. This approach enables an efficient construction of chiral differentially protected vicinal diamines under mild conditions with broad functional group tolerance.