Masayuki Sato, Hirohide Ohuchi, Y. Abe
1992
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0
Influential Citations
14
Citations
Journal
Tetrahedron-asymmetry
Abstract
Abstract Homochiral cis -2-hydroxymethylcyclobutanols, their all cis 3-methyl, and 4-hydroxymethyl derivatives were synthesized from 1,3-dioxin-4-ones via cyclobutane ring formation by [2+2]photocycloaddition, dioxanone ring cleavage, and reduction, followed by lipase-catalyzed kinetic resolution of the resulted cyclobutanols. The chiral cyclobutanols thus obtained have been converted to the corresponding γ-lactones which are potential precursors for a series of biologically active compounds.