Fabio M. da Silva, Andreia M P W da Silva, Mateus Mittersteiner
Jan 2, 2020
Citations
0
Influential Citations
4
Citations
Journal
Tetrahedron Letters
Abstract
Abstract The synthesis of 4-ethoxy-5-hydroxypyrrolidin-2-ones and 6-hydroxyhexahydro-4H-furo[2,3-c]pyrrol-4-ones — through the regio- and stereoselective reduction of the corresponding 3-alkoxysuccinimides — is described. The reaction used NaBH4 at low temperatures and short reaction times, providing products with yields of up to 77%. The stereoselectivity was highly influenced by both alkoxy and the N-moiety in the starting succinimide.