Jun-Liang Zeng, Zhen Chen, Fa‐Guang Zhang
Jul 17, 2018
Citations
0
Influential Citations
34
Citations
Journal
Organic letters
Abstract
Phenylsulfone difluorodiazoethane (PhSO2CF2CHN2), an easy-to-prepare and bench-stable masked CF2-building block, has been developed. The synthetic utility of this reagent is demonstrated by a direct regioselective [3 + 2] cycloaddition with electron-deficient alkynes and alkenes. This protocol enables facile construction of an array of difluoromethyl-substituted pyrazoles in good to high yields under mild reaction conditions.