M. Bagley, M. Lubinu, Christopher Mason
Mar 1, 2007
Citations
0
Influential Citations
46
Citations
Journal
Synlett
Abstract
Reaction of α,β-ethynyl ketones and hydrazine derivatives gives 1,3- and 1,5-disubstituted pyrazoles in good yield. -Microwave irradiation in concentrated hydrochloric acid-methanol (1.5% v/v), with concurrent cooling at sub-ambient temperatures or at 120 °C, for 30 or 2 minutes, respectively, facilitates rapid heterocyclization and preferentially gives the 1,3-disubstituted regio-isomer.