N. Zanatta, L. Fantinel, L. S. Fernandes
Mar 17, 2009
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Journal
ChemInform
Abstract
SYNTHESIS 2008, No. 21, pp 3492–3496xx.xx.2008 Advanced online publication: 16.10.2008 DOI: 10.1055/s-0028-1083178; Art ID: M02908SS © Georg Thieme Verlag Stuttgart · New York Abstract: Three methods for the regiospecific bromination of 2phenyl-3H-pyrimidin-4-ones are presented: bromination of the 5position of the pyrimidine ring, bromination of the 6-benzylic position and simultaneous bromination of both the 5-position of the pyrimidine ring and 6-benzylic position. Reactions were carried out using simple protocols and the brominated pyrimidines were obtained in good yields.