P. Culbert, Jianming Lu, M. Adam
Jun 1, 1997
Citations
0
Influential Citations
6
Citations
Journal
Applied Radiation and Isotopes
Abstract
Abstract The synthesis of methyl 15-(4-trimethylstannylphenyl)pentadecanoate ( p -SnPPA), a precursor for the regiospecific production of 15-(4-[ 123 I]-iodophenyl)pentadecanoic acid, is described. The stannylated precursor is synthesized in six steps from 4-bromophenylacetylene in an overall yield of 16%. p -SnPPA reacts with N.C.A. [ 123 I]NaI in the presence of peracetic acid to yield IPPA in 62% radiochemical yield following hydrolysis.