Jana Hummelova, J. Rondevaldova, A. Balastikova
Mar 1, 2015
Citations
0
Influential Citations
36
Citations
Quality indicators
Journal
Letters in Applied Microbiology
Abstract
In this study, we tested 15 naturally occurring isoflavones and their metabolites for their possible antibacterial properties against nine Gram‐positive and Gram‐negative bacteria. The in vitro antibacterial activity was determined using the broth microdilution method, and the results were expressed as minimum inhibitory concentrations (MICs). 6,7,4′‐trihydroxyisoflavone (demethyltexasin), 7,3′,4′‐trihydroxyisoflavone (hydroxydaidzein), 5,7‐dihydroxy‐4′‐methoxyisoflavone (biochanin A), 7,8,4′‐trihydroxyisoflavone (demethylretusin) and 5,7,4′‐trihydroxyisoflavone (genistein) produced significant antibacterial activity (MICs ≥ 16 μg ml−1). The most effective compound, demethyltexasin, was subsequently tested for its growth‐inhibitory effect against Staphylococcus aureus, and it exhibited significant antistaphylococcal effects against various standard strains and clinical isolates, including methicillin and tetracycline resistant ones with the MICs ranging from 16 to 128 μg ml−1.