W. Morozowich, T. Chulski, W. E. Hamlin
Oct 1, 1962
Citations
0
Influential Citations
22
Citations
Quality indicators
Journal
Journal of Pharmaceutical Sciences
Abstract
Salt formation of benzphetamine and etryptamine as a potential means of obtaining sustained release and/or prolonged action was studied by measuring the median lethal time (LT50) in mice and its relationship to in vitro dissolution rates and solubilities. Both the LT50 and LD50 increase as the in vitro dissolution rate, determined at pH 7.2, decreases. An empirical relationship was found between the LT50 and the in vitro dissolution rate at pH 7.2. The experimental data suggest that salt formation is a potentially useful means of approaching development of sustained-or prolonged-action dosage forms of certain drugs.