M. Kolli, J. Monthéard, J. Vergnaud
Mar 31, 1992
Citations
0
Influential Citations
7
Citations
Journal
International Journal of Pharmaceutics
Abstract
Abstract The present paper describes the use of vinylbenzaldehyde as a monomer carrier of drugs such as benzocaine, procaine, and 2-aminothiazole, or of 4-amino-4H-1,2,4-triazole. The monomer carrier was polymerized, and the subsequent chemical reaction of drug release was investigated using a medium of synthetic gastric liquid. Benzocaine, followed by benzocaine linked to the polymer carrier was dispersed into a matrix composed of Eudragit RL. Analysis of the kinetics of controlled release of benzocaine was carried out on the basis of theoretical considerations and of experimental determination for the case where contact is made with the synthetic gastric liquid. The release of drug was found to be consistent with a process of transient diffusion of liquid. The data obtained on drug release provide the opportunity for the quantitative prediction of the rate of drug release from dosage forms or polymer carrier.