T. Yajima, R. Inoue, M. Matsumoto
Feb 1, 2011
Citations
5
Influential Citations
69
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Journal
The Journal of Physiology
Abstract
Non‐technical summary ACh is the best characterized neurotransmitter that is synthesized in cholinergic neurons in the brain and gut wall. In the gut, acetylcholine is released from the nerve endings in response to luminal stimuli and regulates the movement of gut contents via stimulating muscle contraction and epithelial ion secretion. We show that acetylcholine is synthesized in colonic epithelial cells and released on the serosal side by luminal chemical stimulation of the short chain fatty acid propionate and causes chloride secretion. These results suggest that non‐neuronal release of acetylcholine in response to luminal stimuli plays a role in colonic chloride secretion.