G. Brownlee
Jun 1, 1949
Citations
0
Influential Citations
3
Citations
Journal
Annals of the New York Academy of Sciences
Abstract
The first clinical report on the use of the selectively Gram-negative antibiotic polymyxin A (“Aerosporin”) was the preliminary observations of Swift’ on the treatment of pertussis. This clinical demonstration was restricted to 10 unselected patients, mostly late in the disease, and complicated by secondary invaders, the organism being isolated in only one instance. Swift’s scheme of dosage was between 0.4 to 0.8 mg. per kg., 4hourly for five days, and was related to a blood leve1 of 0.2 pg. to 0.4 pg. per ml. He was able to conclude that the disease was aborted dramatically in early pertussis, and significantly modified in late disease.