Raymond C. B. Wong, Shiang Y. Lim, Sandy S. C. Hung
Mar 26, 2017
Citations
1
Influential Citations
45
Citations
Journal
Aging (Albany NY)
Abstract
Cybrid technology was used to replace Leber hereditary optic neuropathy (LHON) causing mitochondrial DNA (mtDNA) mutations from patient-specific fibroblasts with wildtype mtDNA, and mutation-free induced pluripotent stem cells (iPSCs) were generated subsequently. Retinal ganglion cell (RGC) differentiation demonstrates increased cell death in LHON-RGCs and can be rescued in cybrid corrected RGCs.