Jul 1, 1992
Citations
0
Influential Citations
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Citations
Journal
International Journal of Toxicology
Abstract
4-Nitro-m-Phenylenediamine i s a coal tar cosmetic used at concentrations of ~ 0 . 1 % . In an acute oral toxicity study involving mice, the LD,, was 0.5 g/kg. 4-Nitro-mPhenylenediamine was mutagenic in the chromosome aberrations assay and in the preincubation assay, using strains TA97, TA98, and TA 1537 of Salmonella typhimurium. The safety of use of 4-Nitro-m-Phenylenediarnine in cosmetic products has not been documented and substantiated. The needed safety test data include: methods of production, ultraviolet absorption spectrum, impurities, skin absorption data, adequately performed skin irritation and sensitization studies, and dermal toxicity. It cannot be concluded that this ingredient i s safe for use in cosmetic products until the cited safety data have been obtained and evaluated.