W. Seebacher, H. Berger, M. Kaiser
Apr 5, 2006
Citations
0
Influential Citations
8
Citations
Journal
Monatshefte für Chemie / Chemical Monthly
Abstract
Summary.Several 4-aminobicyclo[2.2.2]octan-2-ones and -ols were synthesized using different pathways. The new compounds were investigated for their activity against Trypanosoma b. rhodesiense, the causative organism of East African sleeping sickness and Plasmodium falciparum the protozoan parasite which causes Malaria tropica. The results are compared to the activities of known compounds and the influence of the substitution of the bicyclo[2.2.2]octane skeleton on the biological activities is discussed.