L. C. Smith, C. G. Skinner, W. Shive
Sep 1, 1961
Citations
0
Influential Citations
6
Citations
Journal
Archives of Biochemistry and Biophysics
Abstract
Abstract Using the typical acetamidomalonic ester synthesis and the appropriate alkyl halides, three new amino acid analogs were prepared, 2-amino-4-ethyl-4-pentenoic acid ( II ), 2-amino-4-ethyl-4-hexenoic acid ( III ), and 2-amino-4-ethylhexanoic acid ( IV ). II was an effective antagonist of phenylalanine for Leuconostoc dextranicum , and IV is a moderately active antagonist of leucine, but III is essentially nontoxic to growth of either L. dextranicum or Escherichia coli . The stereochemical structures and conformations of these and related phenylalanine analogs were correlated with their biological activities.