L. Hui
2005
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0
Influential Citations
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Citations
Quality indicators
Journal
Chinese journal of immunology
Abstract
Objective:Investigate whether adenosine disodium triphosphate for injection can reduce the systemic inflammatory response which induced by cardiopulmonary bypass.Methods:Forty-seven patients scheduled for cardiac surgery over 30 min following CPB were randomly divided into two groups. In treated group(n=23),adenosine disodium triphosphate for injection(2 mmol/L) was added into the prime during CPB, but in control group(n=24), no adenosine disodium triphosphate for injection was added. Blood samples were drawn from the radial artery at the following time points:(1)before CPB;(2)30 min after aortic clamping;(3)30 min after aortic declamping;(4) 12 h after aortic declamping;(5)24 h after aortic declamping.Enzyme-linked immunosorbent assays(ELISA) were used to measure the concentration of tumor necrosis factor-α(TNF-α), interleukin-6(IL-6), in plasma,CK-MB in plasma level were measured too.Results:The concentration of TNF-α?IL-6?CK-MB levels in plasma level of two groups showed no difference before CPB. They all had increased by 30 min after aortic clamping(P0.05). TNF-α?IL-6?CK-MB in the treated group were significantly lower than those in the control group at all time points(P0.05).Conclusion:Adenosine disodium triphosphate for injection can release the concentration of TNF-α?IL-6?CK-MB in plasma after CPB. It suggests that the adenosine disodium triphosphate for injection may protect myocardium and pulmonary during cardiopulmonary bypass.