E. Abignente, A. Sacchi, S. Laneri
1994
Citations
0
Influential Citations
25
Citations
Quality indicators
Journal
European Journal of Medicinal Chemistry
Abstract
Abstract The synthesis of a group of imidazo[1,2-a]pyrimidine-2-carboxylic esters, acids and amides is described. The structures of the new compounds are supported by 1H- and 13C-NMR spectra. These compounds were tested in vivo for their antiinflammatory and analgesic activities as well as for their ulcerogenic action. The ester 5b, the acid 6c and the amide 7a showed antiinflammatory action in the rat paw edema ( ∼1 3 x indomethacin ), while almost all compounds displayed significant analgesic activity in the acetic acid writhing test, particularly the 5-chloro-7-methyl derivatives 5a, 6a and 7a ( ∼1 5 x indomethacin ). All new compounds were found to be lacking in inhibitory activity on cyclooxygenase in vitro.