Qin Yu
2012
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Journal
Journal of Wuhan Polytechnic
Abstract
The research aims to improve the synthetic route of 4-amino-1-naphthalene carbonitrile,which is an important pharmaceutical and chemical intermediate.The naphthylamine was used as raw materials;a compound was prepared by amino protection,nucleophilic substitution,amino unprotection and other steps.The total yield was 81.6%.Results show that the structure of the product was characterized by elemental analysis,IR and 1H NMR,which confirmed that was the target molecule.Thus,the paper concludes that in the process of introducing cyano into the molecular structure,when L-proline is used as catalyst,CuCN reagent for the cyano,the efficiency can be improved significantly and the harm to the environment can be reduced.