Li Ning-wei
2006
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Journal
Chemical Reagents
Abstract
1-(2,3-dichlorophenyl)piperazine is a kind of pharmaceutical intermediate.The paper described two synthetic ways.One was to react 2,6-dichloro-nitrobenzene with anhydrous piperazine and then change the nitryl group to chlorine by acidulation,reduction,Sandmeyer and hydrolysis.Another way was to combine directly anhydrous piperazine with 2,3-dichloro-bromobenzene through Ullmann reaction.The former was better in terms of the quality and quantity of the final product.The total yield was 53.3%.The factors which influence every single reaction were discussed.The structure of 1-(2,3-dichlorophenyl)piperazine was confirmed by IR and(()~1HNMR).