Wang Li
2013
Citations
0
Influential Citations
3
Citations
Journal
Global Traditional Chinese Medicine
Abstract
Aristolonic acid is a nitro phenanthrene organic acid compound found as a main component of Aristolochia,Guan mutong,Asarum,Aristolochia Fangchi and many other medicinal plants. Aristolochic acid is widely used in the pharmaceutical industry due to its anti infection,anti tumor,abortifacient and cellular immunity enhancing properties. Present uses of Aristolochic acid containing Chinese medicine are for the treatment of rheumatic and urinary system diseases. However,there have been increased reports on kidney damage as a result of using Aristolochic acid containing drugs,which,leads to increased research in the field. It is necessary and crucial to provide proper reference for safer clinical use of Chinese traditional medicines with Aristolochic acid components. This paper therefore focuses on the structure,toxicological effects and clinical applications of Aristolochic acid as well as its renal toxicological mechanisms. We therefore conclude that,due to the beneficial medicinal properties of Aristolochic acid,it is necessary to design a safer and effective pharmaceutical dosage formulation and strictly control drug dose and time as well as duration of drug use in order to reduce its toxic effect,thereby increasing its clinical application.