Zhao Ya
2014
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Journal
Global Traditional Chinese Medicine
Abstract
Norcantharidin is a commonly used anti-liver cancer drug with high anti-tumor activity in clinical practice. It can protect liver cells and improve immune functions as well. In recent years,researchers have been focusing on designing active liver-targeting drugs of norcantharidin,such as monoclonal antibody-directed drug or asialoglycoprotein receptor-mediated drug,to improve its specificity to liver as well as to reduce its toxicity to other tissues and organs. This paper reviews the research progress on active liver-targeting drugs of norcantharidin derivertives in recent ten years. All of these researches aim to will provide references to further study and exploitation on clinically available norcantharidin active liver-targeting drugs.