Tao Jian-sheng
2011
Citations
0
Influential Citations
2
Citations
Quality indicators
Journal
Chinese Journal of Experimental Traditional Medical Formulae
Abstract
Objective:To review and analyze the research papers of 20(S)-protopanaxadiol pharmacological activity.Method:References in CNKI,Wan Fang VIP,Springer,Pubmed,Ovid and other databases were accessed for 20(S)-protopanaxadiol,an active compound of troditional Chinese medicine.Some thirty papers in the past 15 years home and abroad were summarized statistically for its pharmacological activity by popularity.Result:20(S)-protopanaxadiol has anti-cancer,anti-depressant actions.It also shows actions of activating chloride ion channel,inhibiting the depolarization of activated sodium Channel,and inhibiting the growth of human embryonic kidney HEK-293 cells and Helicobacter pylori and many other pharmacological activity.Conclusion: The 20(S)-protopanaxadiol′s pharmacological activities are comprehensively summarized,which may give a reference for the medical researchers to carry out the 20(S)-protopanaxadiol pharmacological research in the future.For new drug development,studies on pharmacological mechanisms and toxicity should be carried out in the futnre.