Zhou Liang
2006
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Journal
Journal of Zhejiang University of Technology
Abstract
The 2-chloropropionic acid is an important fine chemical which can be used in the synthesis of a number of chemicals including pesticides,dyestuffs,agriculture chemicals,etc..The optical active 2-chloropropionic acid which has the high physiological activity or the pharmacological action is an important constituent of herbicides,and can be used in producing ibuprofen,the medicine intermediate 2-alanine,methyl chloropropionate as intermediates of agricultural chemicals,ethyl chloropropionate and the preliminary alcohol ester.It may also be used in producing lactic acid.The state-of-art of the recent chiral resolution research of 2-chloropropionic acid and ester was reviewed.Different techniques including the methods of chemistry,biological enzyme,chromatogram and extraction are summarized in detail.Both the advantages and disadvantages of these techniques are compared.It can be concluded that the combination of enzyme catalytic reaction and chemical synthesis is a new resolution way with great potential for 2-chloropropionic acid and ester and also for other chiral substances.