Wang Zuo-guang
2005
Citations
0
Influential Citations
0
Citations
Journal
Chinese New Drugs Journal
Abstract
Sarpogrelate hydrochloride is a novel 5-HT_2 receptor antagonist, which inhibits the 5-HT induced platelet aggregation, vasoconstriction and vascular smooth muscle proliferation, and improves the microcirculation in coronary artery disease (CAD). Sarpogrelate has been found to have beneficial effects in cardiovascular diseases, such as peripheral vascular disease, restenosis after coronary stunting,pulmonary hypertension, and acute and chronic myocardial infarction. The paper is focused on potentials of sarpogrelate as an agent against vascular diseases together with its pharmacological mechanism.