Sun Hai-xia, C. Ying, Ming Yao-lan
2015
Citations
0
Influential Citations
0
Citations
Journal
Guangzhou Chemical Industry
Abstract
3-borono-5-fluorobenzoic acid is an important intermediate for organic synthesis, widely used in organic synthesis, by suzuki aryl-coupling reaction synthesis of olefins, styrene and biphenyl derivative, which is applied to the synthesis of many natural products, organic materials. The use of a two-step reaction synthesis of the target product synthesis process was described using organic lithium reagent synthesis of (3-fluoro-5-methylphenyl) boronic acid. The target product was synthesized using (3-fluoro-5-methylphenyl) boronic acid through the oxidation reaction, the total yield was 75. 5%. This synthetic route is simple with low price of raw material, and accord with the requirement of industrial production to industrial production.