Xu Jian-ju
2014
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Journal
Journal of Jining Medical University
Abstract
Clausenamide,isolated from aqueous extract of dry leaves of Clausena lansium,a Chinese folk medicine,was found to have hepatic protection function and show nootropic activity in animal tests.In order to provide samples for bioresearch and analyze the relationship of structure- activity,various synthesis routes of clausenamide were developed,the synthesis of 16(8 pairs)optically pure stereoisomers of clausenamide with four chiral centers,was achieved,and a series of simplified derivatives were finished.