Yang Yong-zhong
2010
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Journal
Guangzhou Chemical Industry
Abstract
O-Desmethylvenlafaxine was the active metabolite of venlafaxine.As a new antidepressants,O-Desmethylvenlafaxine inhibited uptake of both serotonin and norepinephrine.And in accordance with the different starting materials,venlafaxine,and with 1-[2-amino-1-(4-methoxy)ethyl] cyclohexanol as the starting materials,Synthesis methods for O-demethylation of venlafaxine of antidepressant drug were reviewed and their advantages and disadvantages were described.