Li Yue-hua
2011
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Journal
Journal of Chuxiong Normal University
Abstract
Physostigmine was the earliest known cholinesterase(AChE) inhibitors,which was a kind of alkaloids firstly isolated from the seeds of the African Calabar bean Physostigma venenosum in 1864.It has well biological activity.In clinic it is mainly used for treating glaucoma,atropine and organophosphate intoxication,now also used to treat alzheimer disease(DA).Therefore physostigmine and analogues received widespread concerning and research,the present study focused on the construction of three-ring system and quaternary carbon center of this kind of alkaloids.This paper review the prgress on the total synthesis of physostigmine rescent year.