Sun Jing-guo
2007
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Journal
Journal of Hebei Normal University
Abstract
The new silylating protective route for erythromycin A oxime was researched.Erythromycin A9(o-triphenylsilyl)oxime(TPSEMAO)was first prepared.Influences of solvent,catalysis and silylating reagent to the reaction were detected.The yield reaches more than 90 %.Its structure was analysed and identified by IR,1H NMR and MS.Corresponding stability was investigated.It was revealed that triphenylchlorosilane has a large structural skeleton in connection with erythromycin A oxime,which could affect Macrolide molecular configuration,furthermore,this protective group has characteristic of easy protective and deprotective,it can be used to the new erythromycin products development.