Zeng Peng
2009
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Journal
Anhui Chemical Industry
Abstract
With KH4B as a reducing agent,3-quinuclidinol was synthesized by 3-quinuclidinone hydrochloride in a yield of 80%.With D-(+)-Dibenzoyltartaric acid as a resolution agent,R-3-quinuclidinol was made in acetone and n-propyl alcohol by 3-quinuclidinol in a yield of 20.4%,ee was 98%.3-quinuclidinol after resolution was oxidated PCC to give 3-quinuclidin one hydrochloride in a yield of 85%.The total yield was 18%.