Wang Zhao-yang
2008
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Journal
Anhui Chemical Industry
Abstract
D-camphor-10-sulfonic acid and was used as the initial material to resolute sibutrmine . The diastereomer salt was formed by reacting D-camphor-10-sulfonic with sibutramine in the ethyl acetate. The salt was purified and then disposed by saturation of Na2CO3. Then product was obtained by vaporizing. And resolution yield was 23.6%. The diastereomer salt structure was confirmed through IR,1HMNR.