Luo Mengfei
2012
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Journal
Guangzhou Chemistry
Abstract
2,2-Difluoroethanol was obtained by reduction of ethyl difluoroacetate using sodium borohydride.Effects of reaction temperature,solvents,reaction time,sodium borohydride dosage,and so on were investigated.The results showed that n(NaBH 4)/n(CF 2 HCOOCH 2 CH 3)=0.6,ethanol as solvent at 0℃,the yield of 2,2-difluoroethanol is 98.1% in the reaction.In polarity solvent,with reaction temperature rising(5 ℃and above),the decomposition of the sodium borohydride intensifies,low temperature is favorite for the reaction.