Liu Guo-ji
2009
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Journal
Modern Chemical Industry
Abstract
2,4-Dichloro-5-methoxy-pyrimidine is a new intermediate compound of pyrimidine.In this paper methyl methoxyacetate,methyl formate,carbamide,phosphoryl chloride are used as raw materials to synthesize 2,4-dichloro-5-methoxy-pyrimidine,by cyclization and chloridization.And under optimal conditions the total yield of product can be about 46%,with a purity higher than 99.5%.