Zheng Rui
2010
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Journal
Fine Chemical Intermediates
Abstract
Piperidine-4-carboxylic acid and ethyl carbonochloridate were used as the starting materials for preparation of(2,4-difluorophenyl)(piperidin-4-yl)methanone hydrochloride(4) via amidation,Friedel-crafts acylation and hydration.The staring materials were easily available and the process afforded a reasonable overall yield of 62.4%.The structures of the intermediates and the target compound were identified with 1H NMR.