Sun Xiao-hong
2012
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Quality indicators
Journal
Applied Chemical Industry
Abstract
The optimal synthesis condition of 4-[2-(4,6-D methoxy pyrimidine)]-3-thiourea carboxylic acid phenoxy ester] were investigated via a two-step reaction.The structure of the product was analyzed by hydrogen spectrum(1H NMR),infrared spectroscopy(IR),element analysis and melting temperature measurement.Meanwhile the bacteria inhibition activity of the product was determined in vitro.The results indicated that the total yield of the product was not less than 75% under the optimal condition:0.1 mol chloroformic acid phenyl ester reacted with 0.2 mol potassium thiocyanate at 50 ℃ for 2 h in the presence of ethyl acetate.Then 0.8 mol 4,6-two methoxy-2-amino pyrimidine was added in and reacted at 60 ℃ for 4 h after removing potassium chloride.The product also exhibited a good inhibition and sterilization to the microorganisms which caused plant diseases.