Y. Li-Juan
2012
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Shandong Chemical Industry
Abstract
Hexabromocyclododecane was synthesized by addition reaction of cyclododecatriene with bromine in mixed solvents of alcohol and chloroform.The effect of the ratio of solvents,the way of dropwise addition,mole ratio of substance,dropwise addition time on isomer ratio was studied through a single factor experiment.The optimum synthesis conditions were ascertained as follows: m(alcohol): m(chloroform) = 1 : 1,simultaneously dropwise addition,n(bromine): n(cydlodedecatriene) = 3.5 : 1,dropwise addition time 8 h.Under these conditions,the yield of product could reach 95%,γ isomer ratio could reach 80%.α、β、γ isomer ratio was determined by means of high performance liquid chromatography,seeking for the optimal synthesis conditions.