Song Hong-rui
2009
Citations
0
Influential Citations
1
Citations
Journal
Fine Chemical Intermediates
Abstract
4-(4-Fluorophenyl)-2-(2-methylpropanoyl)-4-oxo-N,β-diphenylbutanamide is a key intermediate of atorvastatin.It was synthesized by condensation of isobutyrylacetanilide obtained from isobutyric acid by chlorination,condensation with meldrum's acid and ammomolysis and 2-bromo-1-(4-fluorophenyl)-2-phenylethanone.The latter was synthesized from phenylacetic acid by chlorination,acylation and bromination.The starting materials in the synthetic route were easily available and the yield was reasonable.The structures of the main intermediates were identified by infrared spectrum,mass spectrum and 1H NMR.