Zhang Heng-qian
2015
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Journal
Journal of Hebei Normal University for Nationalities
Abstract
In the presence of anhydrous ethanol, Ethyl benzoylacetate and 4-Chlorophenylhydrazine hydrochloride was used as raw materials to synthesize title compounds. The optimum conditions were obtained by single factor orthogonal design method experiment: anhydrous ethano l50 ml, dropping time 1 hour, reflux time 3 hours and reflux temperature 80 o C. The best yiled of 1-(4-chlorophenyl)-3-phenyl-1H-pyrazol-5(4H)-one is 99.0% and the purity is higher than 99%.