Zhu Bo
2006
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Journal
Journal of Jilin Institute of Chemical Technology
Abstract
3,4,5-trimethoxybenzaldehyde is synthesized in 71% yield by vanillin method.5-bromovanillin is afforded in 96% yield by the bromination of vanillin with bromine as brominating agents.Treatment of 5-bromovanillin in DMF with sodium methoxide in the presence of cuprous chloride as catalyst gives syringaldehyde in 90% yield,from which 3,4,5-trimethoxybenzaldehyde is obtained by methylation with dimethylcarbonate in 82% yield.