Matthew R. Dintzner, Justin J. Maresh, Charles R. Kinzie
Jan 10, 2012
Citations
0
Influential Citations
29
Citations
Journal
Journal of Chemical Education
Abstract
Students in the undergraduate organic laboratory synthesize tetrahydro-2-(4-nitrophenyl)-4-phenyl-2H-pyran via the Montmorillonite K10 clay-catalyzed reaction of p-nitrobenzaldehye with methanol, 3-buten-1-ol, and benzene. The synthesis comprises an environmentally friendly tandem Prins–Friedel–Crafts-type multicomponent reaction (MCR) and sets the stage for investigation of reaction scope through student research projects with other carbonyl substrates.