S. Conde, M. Fierros, M. I. Rodríguez-Franco
Jul 3, 1998
Citations
0
Influential Citations
10
Citations
Journal
Tetrahedron-asymmetry
Abstract
Abstract Resolution of 1-(4-amino-3-chloro-5-cyanophenyl)-2-bromo-1-ethanol has been achieved by ethanol enantioselective lipase-catalysed alcoholysis, hydrolysis and acylation. Although a good enantioselectivity was observed in the three reactions, the best results were obtained by hydrolysis. This α-bromohydrin is an intermediate in the synthesis of a new adrenergic agent.