K. Sakai, Masami Yokoyama, R. Sakurai
Jun 19, 2006
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Influential Citations
17
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Journal
Tetrahedron-asymmetry
Abstract
Abstract The resolution of 1-cyclohexylethylamine 1 with enantiopure 2-phenylacetic acids via diastereomeric salt formation was investigated. ( R )-2-Methoxy-2-phenylacetic acid 3 and the ( S )-2-phenylpropionic acid 5 were found to be efficient resolving agents for obtaining the single enantiomer ( S )- 1 as the correspondingly less-soluble diastereomeric salt (resolution efficiency = 48% and 52%, respectively).