A. Imura, M. Itoh, A. Miyadera
Sep 4, 1998
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Influential Citations
5
Citations
Journal
Tetrahedron-asymmetry
Abstract
Abstract The important key intermediate of quinolone analogue synthesis, (1S,2S)-2-fluorocyclopropanecarboxylic acid, was prepared enantioselectively by a microbial resolution. One of the strains with the highest enzymatic specificity was selected from soil and when lyophilized cells were treated with corresponding ester, the remaining (1S,2S)-ester was obtained with high enantiomeric purity (98% e.e.).