A. Hurne, J. Simpson, P. Waring
Oct 21, 1997
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Influential Citations
2
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Journal
Bioorganic & Medicinal Chemistry Letters
Abstract
Abstract Epipolythiopiperazine-2,5-diones (ETPs) are an important class of biologically active fungal metabolites. We have successfully synthesised and resolved racemic 1,4-diethyl-3,6-epidithiopiperazine-2,5-dione using chiral HPLC. The biological activities of the enantiomers were investigated to determine the correlation between biological activity and chirality at the bridgehead carbons.